Stimulation of fibroblast proliferation
Fibroblasts are fundamentally important in the process of wound healing. Apart from producing structural proteins such as collagen, they stimulate both angiogenesis and epithelialisation.
In-vitro studies have proven the positive effect of Vivostat® PRF® on fibroblast proliferation. As illustrated below, Vivostat® PRF® increases the growth of normal human skin fibroblasts compared to control.
Furthermore, PRF® performs significantly better than PDGF-BB – the only commercial growth factor approved by FDA for wound treatment.
Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin - Lundquist et al. - Wound Repair and Regeneration 2007; 1-8
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